Risk Factors for Mortality in Patients With Necrotizing Fasciitis: A Systematic Review and Meta‐Analysis

This meta‐analysis was conducted to explore mortality risk factors in necrotizing fasciitis (NF) by analyzing 33 cohort studies ( n = 13,724) from PubMed, Web of Science, Cochrane Library, and Embase up to May 1, 2024. Using Stata 15, we found that significant risk factors included age > 60 years (odds ratio [OR] = 1.04), diabetes mellitus (OR = 1.83), liver cirrhosis (OR = 2.48), chronic kidney disease (OR = 1.63), systolic blood pressure < 90 mmHg measured on admission (OR = 1.92), creatinine > 2.0 mg/dL (OR = 2.75), and hemorrhagic bullae (OR = 2.80). The findings indicate that older age, diabetes, liver cirrhosis, chronic kidney disease, hypotension, elevated creatinine, and hemorrhagic bullae significantly increase NF mortality risk, emphasizing the need for early identification and management of these factors.