Phytochemical Profiling, Anthocyanin Characterization, and In Vivo Evaluation of the Hypoglycemic Activity of Clitoria ternatea L. Flower Extract Cultivated in Vietnam

This study evaluated the hypoglycemic potential of a concentrated extract obtained from Clitoria ternatea extract (CTE), collected from Tay Ninh Province, Vietnam. The extract was obtained by aqueous extraction and characterized using LC–HRMS, revealing the presence of several bioactive compounds, including delphinidin derivatives, kaempferol 3‐(6′‐p‐coumaroyl)‐rutinoside, cyanidin‐3‐(p‐coumaroyl) glucose, and kaempferol‐rhamnosyl‐malonyl‐glucoside. Cyanidin‐3‐(p‐coumaroyl) glucose was identified as the predominant anthocyanin and is considered a major candidate underlying the pharmacological activity of CTE. An in vivo study conducted on Mus musculus mice demonstrated that administration of CTE at a dose of 500 mg/kg body weight exhibited comparable antidiabetic efficacy to gliclazide administered at 10 mg/kg/day. CTE treatment significantly reduced blood glucose levels, with a final mean value of 158.00 mg/dL, indicating its potential antidiabetic activity. Given its established antioxidant and metabolic regulatory properties, cyanidin‐3‐(p‐coumaroyl) glucose is likely to play a central role in the antidiabetic effect observed. Overall, the results emphasize the therapeutic relevance of CTE and warrant further investigation of cyanidin‐3‐(p‐coumaroyl) glucose as a candidate for glycemic regulation.