Iran’s Journey Through Malaria: From Past Challenges to Future Elimination—A Narrative Review

Background Malaria remains a persistent public health concern in Iran, particularly in southeastern regions bordering Afghanistan and Pakistan. Despite substantial progress over recent decades, challenges such as cross‐border transmission, insecticide resistance, and health system disruptions continue to threaten elimination goals. Methods This narrative review synthesized evidence from the World Health Organization (WHO) World Malaria Reports, national surveillance summaries, and peer‐reviewed publications indexed in PubMed and Scopus from 2000 to 2025. Emphasis was placed on case trends, intervention coverage, and cross‐border dynamics. Results Iran reduced indigenous malaria cases dramatically from thousands in the early 2000s to fewer than 300 annually by the mid‐2010s and subsequently recorded multiple consecutive years with zero indigenous transmission, according to the WHO surveillance reports. Key achievements included integrated vector management, community engagement, and strengthened cross‐border initiatives. However, interruptions during the COVID‐19 pandemic and a resurgence of malaria in 2022, largely associated with imported infections, operational disruptions, and emerging vector threats, highlighted vulnerabilities in elimination‐phase systems. Additional challenges such as insecticide resistance and the spread of Anopheles stephensi further complicate the elimination trajectory. Conclusion Iran’s experience illustrates the need for adaptive, multisectoral approaches to malaria control in complex socioecological settings. While elimination remains within reach, achieving the WHO certification will require transparent surveillance metrics, reinforce cross‐border collaboration, and sustain political and financial commitment.