Comparison of the Effectiveness of Grape Seed Extract and Low‐Level Laser Therapy in the Management of Dentin Hypersensitivity: A Randomized Controlled Trial

Objective To evaluate the effectiveness of grape seed extract (GSE) and its combination with low‐level laser therapy (LLLT) in alleviating pain from dentin hypersensitivity (DH) compared to LLLT alone. Methods Patients aged 20–50 years with at least three sensitive teeth in different quadrants and baseline pain scores ≥ 2 on the visual analog scale (VAS) were recruited. Each tooth was randomly allocated to one of three groups: LLLT + placebo, GSE + placebo, or GSE + LLLT. Pain scores were recorded on Days 1, 3, and 7 using cold and air spray tests. Results The GSE + LLLT group demonstrated the greatest reduction in pain sensitivity, showing a 72.8% decrease for air spray and 59.51% for the cold test at Day 3, compared to the LLLT or GSE groups alone. However, there were no statistically significant differences ( P > 0.05) in pain score reduction among the groups at any time point. Discussion The combination of GSE and LLLT may enhance early pain reduction in DH compared to individual treatments, but the improvement was not statistically significant. GSE presents a potentially feasible and patient‐friendly alternative for DH management, warranting further clinical validation. Statistical Analysis Used Data were collected and analyzed using IBM Statistical Package for the Social Sciences (SPSS) software program, Version 20.0 (IBM, Chicago, Illinois). General linear model‐repeated measure ANOVA was carried out to assess the reduction in DH pain score among individual interventions and the comparison between the three interventions. The significance level was set at p < 0.05. Conclusion While GSE combined with LLLT showed the greatest numerical reduction in DH pain scores, the difference was not statistically significant. Further large‐scale studies are recommended to confirm the clinical benefits of this combination. Trial Registration ClinicalTrials.gov identifier: NCT05927831