Innovative Chorioallantoic Membrane Model as Valuable Tool in Diagnostics and Testing of Domestic Animal Cancers

In recent years, particular attention has been paid to the possible connections, similarities, and potential uses of animals, especially pets (dogs and cats), in research on the causes, characteristics, and treatment of cancers occurring in pets and humans. One of the most promising experimental research models used to explore these issues is the avian embryo chorioallantoic membrane (CAM). This review aims to highlight the problem of the occurrence of cancers in domestic animals, placing emphasis on types, incidence, and predispositions of dogs and cats. Methodology and applications in cancer studies of this unique model were presented in detail. Moreover, the advantages and disadvantages of this diagnostic tool, as well as potential and future perspectives, were also described. This review confirms that cancer research can be conducted without the use of animals. Furthermore, the CAM can provide a robust and reliable model for this type of research and provide translational potential as an ethical, cost-effective model bridging laboratory and clinical research.