Figure S8 from SPP1 Drives Colorectal Cancer Liver Metastasis and Immunotherapy Resistance by Stimulating CXCL12 Production in Cancer-Associated Fibroblasts

Figure S8 High plasma SPP1 levels are associated with poor response to immunotherapy in GC patients. A, B Statistical analysis of irOS (A) and irPFS (B) in the SPP1 lower and SPP1 higher groups. C-F Statistical analysis of the best treatment efficacy results in the SPP1 lower and SPP1 higher groups. Data in scatter plots indicate mean ± SEM. ***P < 0.001. Log-rank test (A, B), Student’s t test (C-E), one-way ANOVA (F). CR, Complete Response; PR, Partial Response; PD, Progressive Disease; SD, Stable Disease; irOS, immune-related Overall Survival; irPFS, immune-related Progression-Free Survival; ORR, Objective Response Rate; DCR, Disease Control Rate.