Figure S3 from PRT3789 Is a First-in-Human SMARCA2-Selective Degrader That Induces Synthetic Lethality in SMARCA4-Mutated Cancers

2026 Open access

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Authors: Michael Hulse, Min Wang, Chaoyi Xu, Jack Carter, Anjana Agarwal, Liang Lu, Philip Pitis, Neha Bhagwat, Joseph D. Rager, Justin Kurian, Corey Basch, Monisha Sivakumar
+36 more Jessica Burtell, Arpita Mondal, Alexander Grego, Andrew W. Moore, Carly Bachner, Komali Vykuntam, Anthony Reichelderfer, JiMin Park, Joy M. Cote, Miles Cowart, Olusola Peace Osinubi, Ludovic Bigot, Alice Da Silva, Catline Nobre, Melissandre Meteau, Miguel Soares, Hsin‐Yao Tang, Klare Bersch, Chaofeng Dai, Ganfeng Cao, Bo Shen, Tom Emm, Stefan U. Ruepp, Jennifer Xavier, Chris Tankersley, Diane Heiser, Sang Hyun Lee, Sandy Geeganage, Bruce Ruggeri, Hong Lin, William F. Novotny, Jane Huang, Kris Vaddi, Andrew P. Combs, Peggy Scherle, Koichi Ito
DOI: 10.1158/0008-5472.30986037
Cited by: 0

Abstract

PRT3789 shows species-specific selectivity and induces SMARCA2 degradation through the ubiquitin–proteasome system

Fields of Study & Subjects

Chromatin Remodeling and Cancer Protein Degradation and Inhibitors Mechanisms of cancer metastasis

Publication details

Publication date
2 January 2026