Supplementary Figure S13 from Targeting SUV4-20H Epigenetic Enzymes Enhances Topoisomerase II Poisoning in Prostate Cancer

Fatima Alhourani; Marine Tauziet; Margaux Ayeul; Pierre Dambrun; Hiba Daher; Julie Patouillard; Benoît Miotto; Aurélie Gennetier; Simon George; Xavier Mialhe; Mona Dergham; Florence M. Cammas; Adeline Torro; Diego Tosi; Céline Gongora; Philippe Pourquier; Cyril Ribeyre; Véronique Baldin; Raghida Abou Merhi; Eric Julien

doi:10.1158/0008-5472.30986373

Supplementary Figure S13 from Targeting SUV4-20H Epigenetic Enzymes Enhances Topoisomerase II Poisoning in Prostate Cancer

2026 Open access

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Authors: Fatima Alhourani, Marine Tauziet, Margaux Ayeul, Pierre Dambrun, Hiba Daher, Julie Patouillard, Benoît Miotto, Aurélie Gennetier, Simon George, Xavier Mialhe, Mona Dergham, Florence M. Cammas

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Adeline Torro, Diego Tosi, Céline Gongora, Philippe Pourquier, Cyril Ribeyre, Véronique Baldin, Raghida Abou Merhi, Eric Julien

DOI: 10.1158/0008-5472.30986373

Cited by: 0

Abstract

Figure S13 shows H4K20 methylation levels, chromatin binding of BRCA1 and BARD1, and focal accumulation of BRCA1, RPA, and RAD51 in WT and SUV4-20H1/H2 KO DU145 cells treated with etoposide.

Fields of Study & Subjects

Cancer therapeutics and mechanisms Histone Deacetylase Inhibitors Research Prostate Cancer Treatment and Research

Publication details

Publication date: 2 January 2026