Figure S7 from CRISPR-Cas9 Screening Identifies Resistance Mechanisms to KRAS Inhibition in Pancreatic Cancer

2026 Open access

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Authors: Szu-Aun Long, Haley Todd, Grace Goodhart, Wen-Hsuan Chang, Amber M. Amparo, Rachel Bridgens, Julien Dilly, Se Jun Park, Robert M. Beal, Sara M. Shehadeh, Megan A. Satyadi, Vidushi K. Trivedi
+13 more Sarah E. Ackermann, Raivath Mukherjee, Craig M. Goodwin, A. Tudor Edwards, Clint A. Stalnecker, Kenneth D. Greis, Andrew J. Aguirre, G. Aaron Hobbs, Kirsten L. Bryant, Syed Kamran Ahmad, Adrienne D. Cox, Channing J. Der, Andrew M. Waters
DOI: 10.1158/0008-5472.31345608
Cited by: 0

Abstract

MRTX1133-resistant PDAC cell lines exhibit similarities and differences compared to RMC-7977-resistant cell lines.

Fields of Study & Subjects

Pancreatic and Hepatic Oncology Research CRISPR and Genetic Engineering Protein Kinase Regulation and GTPase Signaling

Publication details

Publication date
16 February 2026
Language
EN