Supplementary Figure S12 from PI3Kα Inhibitor and Degrader Inavolisib Can Co-opt FGFR2 to Enhance Responses in Patients with PIK3CA-Mutated Solid Tumors and in Preclinical Models

2026 Open access

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Authors: Dejan Juric, Kyung Song, Radia Marie Johnson, Melissa Kate Accordino, Philippe Lucien Bedard, Andrés Cervantes, Valentina Gambardella, Erika Paige Hamilton, Antoîne Italiano, Kevin Kalinsky, Ian E. Krop, Mafalda Oliveira
+34 more Cristina Saura, Peter Schmid, Nicholas C. Turner, Andreea Varga, Steven B. Gendreau, Michael S.H. Hwang, Zheng Kuang, Jeffrey Lau, Eva Lin, Trang Pham, Danilo Maddalo, Matthew G. Rees, Melissa M. Ronan, Jennifer A. Roth, Scott Martin, Nicole M. Sodir, Ethan S. Sokol, Zachary J. Whitfield, Alice Wong, Robert L. Yauch, Junko Aimi, Sravanthi Cheeti, Jill O. Fredrickson, Stephanie Hilz, Marc A. Hafner, Katherine E. Hutchinson, Yanling Jin, Ubong Peters, Daniel Zingg, Stephanie Royer‐Joo, Noopur Shankar, Jennifer L. Schutzman, Komal L. Jhaveri, Anwesha Dey
DOI: 10.1158/1078-0432.31006750
Cited by: 0

Abstract

Evaluation of the anti-tumor activity of FGFR2 inhibitor in combination with inavolisib in MFM223x2.2 xenograft model

Fields of Study & Subjects

Fibroblast Growth Factor Research Eosinophilic Disorders and Syndromes Gastrointestinal Tumor Research and Treatment

Publication details

Publication date
6 January 2026