Figure 4 from Clinical and Genomic Factors Associated with Elacestrant Outcomes in ESR1-Mutant Metastatic Breast Cancer

Differences in elacestrant efficacy in patients with polyclonal versus single ESR1-mutant tumors. Among this cohort of patients with a baseline ESR1 mutation detected within 6 months of elacestrant start, clinical outcomes in patients with two, three, or four or more detectable ESR1 alterations were compared with patients with one ESR1 mutation. A depicts the TTNT on elacestrant, B depicts the TTD, and C depicts the OS comparing those with two ESR1 mutations in red, three in green, and four or more in brown against patients with a single ESR1 mutation in blue. The adjusted HR and corresponding 95% CI are displayed. Vertical hash marks denote a censored patient event. ESR1 alt denotes ESR1 alteration. alt, alteration; CL, confidence limit; pts, patients.