Figure 1 from Real-World Outcomes of Elacestrant in ER+, HER2−, ESR1-Mutant Metastatic Breast Cancer

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Authors: Hope S. Rugo, Virginia Kaklamani, Heather L. McArthur, Seth Andrew Wander, William John Gradishar, Reshma Mahtani, Mark Daniel Pegram, Maryam B. Lustberg, Elyse Swallow, Jessica Maitland, Sebastian Kloss, Tomer Wasserman
+1 more Sara M. Tolaney
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Abstract

mTTNT benefit in clinical subgroups: (A) 1–2 prior lines of ET ± CDK4/6i, (B) 1–2 prior lines of ET ± CDK4/6i ≥ 12 months, (C) 1 prior line of ET ± CDK4/6i, (D) 2 prior lines of ET ± CDK4/6i, (E) ≥3 prior lines of ET ± CDK4/6i, (F) visceral metastasis, (G) coexisting ESR1 and PI3K pathway mutations, (H) no prior fulvestrant, and (I) no prior chemotherapy.

Fields of Study & Subjects

Advanced Breast Cancer Therapies PARP inhibition in cancer therapy PI3K/AKT/mTOR signaling in cancer

Publication details

Publication date
6 January 2026