Figure 5 from Associations of the HER2DX Genomic Test with Biological and Pathologic Features in HER2-Positive Breast Cancer

Correlations between HER2DX molecular modules and pathology features. Heatmap of Pearson correlation coefficients between HER2DX scores/modules (pCR score, risk score, ERBB2 score, IGG, proliferation, and luminal) and pathologic features (TIL%, Ki67, HR status, TLS, HER2 IHC, tumor grade, and spatial pattern; A); scatter plots showing IGG score vs. TIL% (B), proliferation score vs. Ki67% (C), luminal score vs. binary HR status (D), and luminal score vs. ER % levels (E). Correlation values and P values are shown; positive correlations reflect biological concordance between genomic and pathologic features. Statistical comparisons were performed using appropriate parametric tests.