Molecular Characterization of KLK2 RNA Expression in Prostate Cancer

Clinical Cancer Research 2026

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Authors: Rana R. McKay, Shayan S. Nazari, A. Elliott, Norm D. Smith, Pedro Coelho Barata, Deepak Kilari, Rohan Garje, Michael C. Haffner, Colm M. Morrissey, Brent A. Rupnow, Subhasree Basu, Charles G. Drake
+5 more Brent Shane Rose, Aditya Bagrodia, Neeraj Agarwal, Emmanuel S. Antonarakis, Himisha Beltran
DOI: 10.1158/1078-0432.ccr-25-4293
Cited by: 0
References: 22

Abstract

PURPOSE: KLK2 is an androgen-regulated gene critical in prostate cancer biology with multiple KLK2-targeted therapies in clinical development. We investigated KLK2 RNA expression patterns and associations with molecular features to provide context for emerging KLK2-targeted treatments. EXPERIMENTAL DESIGN: DNA/RNA next-generation sequencing was performed on 7,078 prostate cancer specimens. KLK2-high/low RNA expression was defined as ≥75th/

Fields of Study & Subjects

Prostate Cancer Treatment and Research Prostate Cancer Diagnosis and Treatment Breast Cancer Treatment Studies

Publication details

Journal / source
Clinical Cancer Research
Volume
32
Issue
11
Pages
2293–2304
Publication date
12 March 2026
Language
EN