Abstract LT001: Exploiting the dependency on DDX19A to induce transcriptional catastrophe in Ewing sarcoma

Cancer Research 2026

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Authors: Saikat Chakraborty, Victoria Akingbehin, Daniel Estévez Prado, John Harper, Abigail Fish2, Tommaso Cupido, Lillian M. Guenther
DOI: 10.1158/1538-7445.fusionpositive26-lt001
Cited by: 0

Abstract

Abstract Ewing sarcoma (ES) is an aggressive pediatric malignancy driven by the EWS/FLI1 oncofusion, which reprograms enhancers, enforces transcriptional reprogramming, and imposes high levels of replication stress. Multimodal therapy yields ∼70% survival in localized ES, but

Fields of Study & Subjects

Sarcoma Diagnosis and Treatment Chromatin Remodeling and Cancer Genomics and Chromatin Dynamics

Publication details

Journal / source
Cancer Research
Volume
86
Issue
1_Supplement
Pages
LT001–LT001
Publication date
13 January 2026
Language
EN