Figure S5 from RAS Mutation–Specific Responses to Paralog- and State-Selective RAS Inhibitors

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Authors: Beau Baars, Ana Orive-Ramos, Matthew J. Emmett, Bijaya Gaire, Mathieu Desaunay, Ziyue Kou, Guangyan Li, Christos Adamopoulos, Stuart A. Aaronson, Shaomeng Wang, William R. Sellers, Tiphaine C. Martin
+2 more Evripidis Gavathiotis, Poulikos I. Poulikakos
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Abstract

Sensitivity to any single RAS-targeted inhibitor is restricted to the subset of RAS(MUT)-specific inhibitor-sensitive tumors

Fields of Study & Subjects

Melanoma and MAPK Pathways Protein Degradation and Inhibitors PI3K/AKT/mTOR signaling in cancer

Publication details

Publication date
2 January 2026