Supplementary Figure 6 from Combined MYC Activation and PTEN Loss Drives Molecular Features of Aggressive Preinvasive Lesions in Mouse Prostate

Michael Rubenstein; Apurv Rege; Gretchen K. Hubbard; Danielle Cannady; Shreya Agarwal; Kevin Chen; Alex Estrada; Carolina Gomes-Alexandre; Jessica L Hicks; Tracy Jones; Qizhi Zheng; Srinivasan Yegnasubramanian; Charles J. Bieberich; Angelo M. De Marzo

doi:10.1158/1541-7786.30985985

Supplementary Figure 6 from Combined MYC Activation and PTEN Loss Drives Molecular Features of Aggressive Preinvasive Lesions in Mouse Prostate

2026 Open access

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Authors: Michael Rubenstein, Apurv Rege, Gretchen K. Hubbard, Danielle Cannady, Shreya Agarwal, Kevin Chen, Alex Estrada, Carolina Gomes-Alexandre, Jessica L Hicks, Tracy Jones, Qizhi Zheng, Srinivasan Yegnasubramanian

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Charles J. Bieberich, Angelo M. De Marzo

DOI: 10.1158/1541-7786.30985985

Cited by: 0

Abstract

Barcode plots for ‘Ribosome Biogenesis’, ‘Cytoplasmic Translation’, and ‘tRNA Processing’ pathways in PIN samples. All three pathways are positively enriched in MYC-PIN and BMPC-PIN samples, and negatively enriched in PTEN-Null PIN samples.

Fields of Study & Subjects

PI3K/AKT/mTOR signaling in cancer RNA modifications and cancer Cancer-related molecular mechanisms research

Publication details

Publication date: 2 January 2026