Supplementary Figure 5 from Combined MYC Activation and PTEN Loss Drives Molecular Features of Aggressive Preinvasive Lesions in Mouse Prostate

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Authors: Michael Rubenstein, Apurv Rege, Gretchen K. Hubbard, Danielle Cannady, Shreya Agarwal, Kevin Chen, Alex Estrada, Carolina Gomes-Alexandre, Jessica L Hicks, Tracy Jones, Qizhi Zheng, Srinivasan Yegnasubramanian
+2 more Charles J. Bieberich, Angelo M. De Marzo
Cited by: 0

Abstract

Gene expression across five translation-related pathways for Pten-Null PIN samples is comparable to or less than wild-type samples, and expression increases in MYC-PIN and BMPC-PIN, with expression of some genes increasing even higher in primary and metastatic samples.

Fields of Study & Subjects

PI3K/AKT/mTOR signaling in cancer Prostate Cancer Treatment and Research Mechanisms of cancer metastasis

Publication details

Publication date
2 January 2026