Supplementary Figure 3 from Combined MYC Activation and PTEN Loss Drives Molecular Features of Aggressive Preinvasive Lesions in Mouse Prostate

Michael Rubenstein; Apurv Rege; Gretchen K. Hubbard; Danielle Cannady; Shreya Agarwal; Kevin Chen; Alex Estrada; Carolina Gomes-Alexandre; Jessica L Hicks; Tracy Jones; Qizhi Zheng; Srinivasan Yegnasubramanian; Charles J. Bieberich; Angelo M. De Marzo

doi:10.1158/1541-7786.30985994

Supplementary Figure 3 from Combined MYC Activation and PTEN Loss Drives Molecular Features of Aggressive Preinvasive Lesions in Mouse Prostate

2026 Open access

Read full text

Authors: Michael Rubenstein, Apurv Rege, Gretchen K. Hubbard, Danielle Cannady, Shreya Agarwal, Kevin Chen, Alex Estrada, Carolina Gomes-Alexandre, Jessica L Hicks, Tracy Jones, Qizhi Zheng, Srinivasan Yegnasubramanian

+2 more

Charles J. Bieberich, Angelo M. De Marzo

DOI: 10.1158/1541-7786.30985994

Cited by: 0

Abstract

Wild-type FVB, MYC-PIN, PTEN-Null PIN, BMPC-PIN, and BMPC primary tissue stained with H&E, and IHC staining for PTEN and phospho-AKT. Positive phospho-AKT staining in the epithelium of FVB and PIN samples is concordant with negative staining for PTEN. All tumor cells stain positively for phospho-AKT and negatively for PTEN.

Fields of Study & Subjects

PI3K/AKT/mTOR signaling in cancer Prostate Cancer Treatment and Research Inflammatory mediators and NSAID effects

Publication details

Publication date: 2 January 2026