Supplementary Figure 1 from Combined MYC Activation and PTEN Loss Drives Molecular Features of Aggressive Preinvasive Lesions in Mouse Prostate

Volcano plots for PTEN-Null PIN, MYC-PIN, and BMPC-PIN compared to their respective wild-type lobes with differentially expressed genes (yellow), CCP score genes (labeled), and genes in proliferation associated GO-BP pathways (blue) mitotic spindle organization (A), cell division (B), chromosome segregation (C), DNA replication (D), G2/M transition mitotic cytokinesis (E), and cell cycle (F). (G) Volcano plots depicting the top PC1 genes that drove enrichment of the proliferation associated GO-BP pathways in A-F (blue).