Supplementary File S1 from PCSK5M452I Is a Recessive Hypomorph Exclusive to MCF10DCIS.com Cells

DEseq2 analysis of 3D spheroids prepared from MCF10DCIS.com cells reconstituted with wild-type (WT), hypomorphic (M452I), or null (T288P) PCSK5, and PCSK5T288P cultured with 250 ng/mL GDF11 for 8 days. Worksheets compare GDF11 relative to T288P, WT relative to T288P, and WT relative to M452I. Each sheet reports the log2 fold change, standard error (SE), DEseq2 statistics, and the mean and modeled counts for each condition from N = 4 biological replicates.