Abstract GS2-12: Radiation doses and fractionation schedules in non-low-risk ductal carcinoma in situ in the breast (BIG 3-07/TROG 07.01): final 10-year analysis of a randomised, factorial, multicentre, open-label, phase 3 study

Clinical Cancer Research 2026

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Authors: BH Chua, E. K. Link, Ivo A. Olivotto, Ian H. Kunkler, Timothy Joseph Whelan, Pieter R.A.J. Deseyne, Günther Gruber, BIG 3-07/TROG 07.01 trial investigators
DOI: 10.1158/1557-3265.sabcs25-gs2-12
Cited by: 0

Abstract

Abstract Background: Whole breast irradiation (WBI) after breast conserving surgery for ductal carcinoma in-situ (DCIS) reduces local recurrence. We aimed to evaluate whether a tumor bed boost after WBI improved long-term outcomes, and examine radiation dose fractionation sensitivity for non-low-risk DCIS. Methods: The study was an international, randomized, unmasked, phase 3 trial involving 136participating centers from six clinical trials organizations in 11 countries. Eligible patients were women aged ≥18 years who had breast conserving surgery with ≥1 mm of clear radial resection margins for unilateral, histologically proven, non-low-risk DCIS defined as age

Fields of Study & Subjects

Breast Cancer Treatment Studies Breast Lesions and Carcinomas Advanced Radiotherapy Techniques

Publication details

Journal / source
Clinical Cancer Research
Volume
32
Issue
4_Supplement
Pages
GS2–12
Publication date
17 February 2026
Language
EN