Abstract PD13-05: Clinical-pathological patterns and prognosis of young women with breast cancer brain metastases: a single-centre retrospective study

Abstract Background: Breast cancer (BC) is the most frequent cancer among women and the second leading cause of central nervous system (CNS) metastases. Given limited data regarding the impact of young age on outcomes of women with metastatic breast cancer (MBC) and CNS metastases, we compared the clinical-pathological features, treatment patterns and outcomes of women ≤40 and those ≥40 years-of-age with CNS metastases in an established single-centre retrospective cohort. Methods: Patients with MBC and CNS metastases who were treated with surgery, whole-brain radiotherapy (WBRT), or stereotactic radiosurgery (SRS) at the Sunnybrook Odette Cancer Centre, Toronto, Canada between 2008 and 2018 were included. Clinical data was abstracted from electronic medical records. Patient characteristics were described with medians and interquartile ranges for continuous variables and percentages for categorical variables. Categorical variables were compared between young (