Abstract PS1-01-14: Comparing Functional Measures and Their Associations with Toxicity and Survival in Older Adults with Early Breast Cancer: Results from the Prospective Multicenter HOPE Study

Abstract Background: Clinicians infrequently use geriatric assessment in routine care, despite its superior ability to identify at-risk older adults with early breast cancer compared to clinician-rated Karnofsky Performance Status (cKPS). Asking patients to rate their own performance status may offer a more scalable alternative, but the relationship between patient-reported KPS (pKPS) and treatment outcomes is unknown. We hypothesized that pKPS would show stronger associations with treatment outcomes than cKPS but similar associations as geriatric assessment-based frailty. Methods: The HOPE study enrolled 499 women aged >65y with stage I-III breast cancer across 16 US sites who were planned to start neo/adjuvant chemotherapy. At baseline, we obtained a geriatric assessment-based Deficit Accumulation Frailty Index (DAFI; categorized as robust [DAFI 0.2]). cKPS and pKPS were collected and categorized as high [KPS>=80] or low [KPS