Abstract PS1-05-17: Impact of circuit based exercise in breast cancer survivorship

Abstract Introduction: Adjuvant chemotherapy (AdjCTx) in breast cancer patients is associated with muscle weakness, fatigue, and functional decline that may persist into survivorship. While exercise is recognized as a supportive intervention, the role of circuit-based exercise (CBE) during active chemotherapy remains underexplored. This study investigated the feasibility and functional outcomes of a supervised CBE program in breast cancer patients with or without concurrent AdjCTx. Methods: This study included 40 postoperative breast cancer patients who completed a CBE program for at least two months between June 2020 and April 2023. Patients were stratified into AdjCTx (+) (n = 20) and AdjCTx (-) (n = 20) groups. The CBE protocol, delivered via the Milon® system, integrated aerobic and eccentric resistance training at 60% of one-repetition maximum. Functional outcomes included isokinetic knee extensor strength (peak torque), gait speed (10-meter walk test), balance (Berg Balance Scale), and mobility (Timed Up and Go). Body composition was assessed using bioelectrical impedance analysis. Within-and between-group changes were analyzed using repeated measures ANOVA and paired t-tests. Results: Both groups demonstrated significant improvements in knee extensor strength over time (P