Abstract PS1-09-14: Evaluating clinical and molecular correlates of Inflammatory Breast Cancer using a scoring system-based chart review

Abstract Background: Inflammatory breast cancer (IBC) is a rare and aggressive form of breast cancer with a distinct clinical presentation and poor prognosis. Diagnostic ambiguity remains a challenge, and recent literature has proposed structured criteria to improve case classification. Methods: We conducted a retrospective chart review of 83 patients diagnosed with IBC and 83 patients with non-inflammatory breast cancer (non-IBC), seen at the University of Texas Southwestern Medical Center as part of the Dallas Metastatic Cancer Study. Each IBC case was evaluated using a structured scoring system adapted from the diagnostic guidelines proposed by Omarini et al. (2022) to assess the degree of conformity to established IBC features. Clinical and pathological characteristics were compared across groups using appropriate statistical tests. Results: Our findings reinforce several established associations in the literature. Compared to non-IBC patients, those with IBC exhibited significantly higher Ki-67 proliferation indices (1.42-fold increase, p