Abstract PS2-01-25: Does surgery in a specialized clinic improve locoregional recurrence rates in Inflammatory Breast Cancer?

Abstract Background: Our institution has a specialized Inflammatory Breast Cancer (IBC) clinic (SIBCC) where almost all patients undergo trimodality therapy. Surgical management for IBC at SIBCC routinely consists of modified radical mastectomy to negative margins along with an axillary lymph node dissection after completion of neoadjuvant systemic therapy. We sought to evaluate the differences in surgical outcomes between patients who underwent surgery at SIBCC versus patients who underwent surgery at outside institutions (OSI). Methods: A retrospective analysis was performed on patients with IBC enrolled in a prospective registry from 2003-2025 at SIBCC. All patients underwent surgery for primary tumor removal either at SIBCC or an outside institution. Chi-squared test and Kaplan-Meier method were used for statistical analysis. Results: Of the 920 patients included, 620 had their surgical procedures completed at SIBCC, while 300 had surgery at OSI. Patients underwent the following surgical procedures: modified radical mastectomy (SIBCC: 620, 100%; OSI: 249, 83%), total mastectomy (SBICC: 0; OSI: 35, 11.7%), skin sparing mastectomy (SIBCC: 0; OSI: 5, 1.7%), and segmental mastectomy (SIBCC: 0; OSI: 5, 1.7%). Axillary lymph node dissections were performed in 96% of cases at SIBCC and 83% of cases at OSI. Pathologic nodal positivity was higher in the OSI group (40%) compared to the SIBCC group (31% p=0.021). Patients treated at outside institutions were significantly more likely to have positive surgical margins (63.2%) compared to those treated at SIBCC (2.5%, P