Abstract PS4-01-02: A Comparative Analysis of TAR and NLR in Patients with triple negative breast cancer treated with as KEYNOTE-522 trial : Distinct Predictors of Pathologic Response and Survival

Abstract Background) Pathologic complete response (pCR) has been widely used as a surrogate marker for relevant outcomes in breast cancer patients undergoing neoadjuvant treatment. However, the prognostic value of pCR varies by subtype, with triple-negative breast cancer (TNBC) showing one of the strongest associations. Notably, some patients achieving pCR still experience recurrence, suggesting that pCR and survival outcomes such as event-free survival (EFS) may represent distinct biological endpoints from different processes. This study investigated whether the tumor-aorta ratio based on Hounsfield units (TAR) and the neutrophil-to-lymphocyte ratio (NLR) function as distinct predictive biomarkers for pCR and EFS in TNBC patients treated with the KEYNOTE-522 regimen. Materials and Methods) Patients with TNBC who received neoadjuvant systemic therapy according to the KEYNOTE-522 regimen were included. Clinicopathologic data, including TAR and NLR values, were collected and analyzed. Group comparisons were performed using independent t-tests or Mann-Whitney U tests, as appropriate. Statistical analyses were conducted using SPSS version 29, with a p-value