PS4-05-19: Enumeration of circulating tumor cell (CTC) clusters as a function of age or neutrophil -to-lymphocyte-ratio (NLR) in women with metastatic breast cancer

Clinical Cancer Research 2026

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Authors: Marcus Hermann Friedrich Vetter, T. Kanthaiah, Elena-Diana Chiru, Francesc Castro-Giner, Ilona Krol, Andreas N. WICKI, Alexander Ring, Bich Doan Nguyen-Sträuli, V. Heinzelmann-Schwarz, W. Weber, C. Kurzeder, Nicola Aceto
+1 more Fabienne Dominique Schwab
DOI: 10.1158/1557-3265.sabcs25-ps4-05-19
Cited by: 0

Abstract

Abstract Background: CTC clusters are established mediators of metastasis in breast cancer and are associated with unfavorable clinical outcomes. However, their prevalence and phenotypic characteristics in older patient populations remain inadequately studied. Systemic inflammation, as measured by the NLR, may influence CTC dynamics. Methods: A prospective translational analysis was conducted in women with metastatic breast cancer (mBC), stratified into two cohorts: Group A (age ≥70 years) and group B (age

Fields of Study & Subjects

Cancer Cells and Metastasis Inflammatory Biomarkers in Disease Prognosis Cancer Genomics and Diagnostics

Publication details

Journal / source
Clinical Cancer Research
Volume
32
Issue
4_Supplement
Pages
PS4–05
Publication date
17 February 2026
Language
EN