Abstract PS4-11-30: A Retrospective Review of Demographics and BMI on ER Positive and Negative Breast Cancer in Rural Southeast Alabama

Abstract Background: Breast cancer remains a leading health concern among women, with Estrogen Receptor (ER) status influencing prognosis and treatment. Rural populations often face disparities in access and outcomes, yet data remains limited. This study evaluates the relationship between Body Mass Index (BMI), demographics, and ER status in breast cancer patients from Southeast Alabama. By analyzing a large rural cohort, we highlight how elevated BMI, type 2 diabetes, tobacco use, race, and family history may influence ER(+) disease, offering insights that may guide future preventive strategies and targeted screening efforts in underserved communities. Methods: We reviewed data from July 2018 to June 2025 using our institution’s Epic database, SLICER DICER. BMI was categorized according to the World Health Organization (WHO) adult classification. International Classification of Disease (ICD) codes were used to extract data from Slicer Dicer. The study population (n=1421) consisted of individuals from rural communities in Southeast Alabama. Results: Comparisons were made between ER(+) breast cancer and ER(-) breast cancer in adult BMI classifications per WHO. Average age for ER(+) breast cancer was 70.1+.7 years and average age for ER(-) breast cancer was 73.1+.7 years. The ER(+) population was 70.9% white, 26.6% black, and 2.5% other. The ER(-) population was 62% white, 37.1% black, and 0.9% other. Comparisons between BMI for ER(+) vs ER(-) breast cancer respectively; BMI less than 18.5 was 2.67% vs 2.83%; BMI 18.5-25, 18.08% vs 17.56%; BMI 25-30, 29.34% vs 26.91%; BMI 30-35, 24.34% vs 25.5%, BMI 35-40, 15.62% vs 17%. Comparison with respect to Type 2 Diabetes Mellitus diagnosis for ER(+) vs ER(-) breast cancer respectively was 31%+3.2% vs 30.4+6.7%. Comparison with respect to positive family history for ER(+) vs ER(-) breast cancer respectively was 30.9%+3.3% vs 36.5%+7%. The comparison of tobacco use with respect to ER (+) vs ER(-) breast cancer was 40.1%+3.4% vs 40.9%+7.2%. Analysis using χ2 test (χ2=889.32) with p