Supplementary Figure 4 from Genome-wide CRISPR Screening Reveals a PKA-Driven Resistance Mechanism to Metformin for Oral Cancer Prevention That Can Be Exploited by Combination with NSAIDs

Thomas S. Hoang; Farhoud Faraji; Amaya N. Mendez-Molina; Sendi Rafael Adame-Garcia; Kuniaki Sato; Tomohiko Ishikawa; Pham Thuy Tien Vo; Sydney I. Ramirez; Paola Y. Anguiano Quiroz; Tracy Guo; Katie Fan; Xingyu Wu; Alfredo Molinolo; Ezra E.W. Cohen; Prashant Mali; Scott Michael Lippman; Jorge Silvio Gutkind

doi:10.1158/1940-6207.31276818

Supplementary Figure 4 from Genome-wide CRISPR Screening Reveals a PKA-Driven Resistance Mechanism to Metformin for Oral Cancer Prevention That Can Be Exploited by Combination with NSAIDs

2026 Open access

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Authors: Thomas S. Hoang, Farhoud Faraji, Amaya N. Mendez-Molina, Sendi Rafael Adame-Garcia, Kuniaki Sato, Tomohiko Ishikawa, Pham Thuy Tien Vo, Sydney I. Ramirez, Paola Y. Anguiano Quiroz, Tracy Guo, Katie Fan, Xingyu Wu

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Alfredo Molinolo, Ezra E.W. Cohen, Prashant Mali, Scott Michael Lippman, Jorge Silvio Gutkind

DOI: 10.1158/1940-6207.31276818

Cited by: 0

Abstract

Supplementary Figure 4. Metformin promotes upregulation of COX2 in 4NQO carcinogen-induced oral premalignant lesions. (Related to Figure 3)

Fields of Study & Subjects

Metabolism Diabetes and Cancer Cancer Hypoxia and Metabolism Head and Neck Cancer Studies

Publication details

Publication date: 6 February 2026