Supplementary Text 1 from Development and Prospective Validation of a Cell-free DNA–Based Model for the Early Detection of Pancreatic Cancer

This document provides detailed descriptions of patient recruitment procedures for the case-control cohort, methods for genomic feature extraction, model construction and training, statistical analyses, feature importance assessment, and both in silico and experimental evaluations of the limit of detection. It also includes the design of the prospective screening cohort and comprehensive clinical information on the pancreatic cancer–related cases identified therein.