Figure S5 from EML4−ALK Variant-Specific Genetic Interactions Shape Lung Tumorigenesis

2026 Open access

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Authors: Alberto Diaz-Jimenez, Emily G. Shuldiner, Kálmán Somogyi, Karen Y. Shih, Óscar González-Velasco, Mulham Najajreh, Stewart J. Kim, Filiz Akkas, Christopher W. Murray, Laura Andrejka, Min Kuan Tsai, Benedikt Brors
+8 more Ilse Hofmann, Smruthy Sivakumar, Saumya Dushyant Sisoudiya, Ethan S. Sokol, Hongchen Cai, Dmitri A. Petrov, Monte M. Winslow, Rocı́o Sotillo
DOI: 10.1158/2159-8290.31047243
Cited by: 0

Abstract

Supplementary Figure 5 shows the schematic of Lenti-sgTSG75-sgV1/Cre and Lenti-sgTSG75-sgV3/Cre pools, tumor initiation in Cas9-negative mice to determine the representation of Lenti-sgRNA/Cre vectors, and additional data from broader screen of tumor suppressor function in V1- and V3-driven lung cancer including tumor burden, tumor number and effect.

Fields of Study & Subjects

Lung Cancer Treatments and Mutations CRISPR and Genetic Engineering Lung Cancer Research Studies

Publication details

Publication date
12 January 2026