Figure S3 from EML4−ALK Variant-Specific Genetic Interactions Shape Lung Tumorigenesis

Alberto Diaz-Jimenez; Emily G. Shuldiner; Kálmán Somogyi; Karen Y. Shih; Óscar González-Velasco; Mulham Najajreh; Stewart J. Kim; Filiz Akkas; Christopher W. Murray; Laura Andrejka; Min Kuan Tsai; Benedikt Brors; Ilse Hofmann; Smruthy Sivakumar; Saumya Dushyant Sisoudiya; Ethan S. Sokol; Hongchen Cai; Dmitri A. Petrov; Monte M. Winslow; Rocı́o Sotillo

doi:10.1158/2159-8290.31047249

Figure S3 from EML4−ALK Variant-Specific Genetic Interactions Shape Lung Tumorigenesis

2026 Open access

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Authors: Alberto Diaz-Jimenez, Emily G. Shuldiner, Kálmán Somogyi, Karen Y. Shih, Óscar González-Velasco, Mulham Najajreh, Stewart J. Kim, Filiz Akkas, Christopher W. Murray, Laura Andrejka, Min Kuan Tsai, Benedikt Brors

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Ilse Hofmann, Smruthy Sivakumar, Saumya Dushyant Sisoudiya, Ethan S. Sokol, Hongchen Cai, Dmitri A. Petrov, Monte M. Winslow, Rocı́o Sotillo

DOI: 10.1158/2159-8290.31047249

Cited by: 0

Abstract

Supplementary Figure 3 show schematic of diversification of the Lenti-sgTSG19-sgV1/Cre and Lenti-sgTSG19-sgV3/Cre pools and tumor initiation in Cas9-negative mice, additional explanation of adaptive sampling method used in assessing the impact of Lenti-sgRNA/Cre vectors in V1- and V3-driven models and additional data on tumor suppressor function in V1- and V3-driven lung cancer including tumor burden, tumor number and effect.

Fields of Study & Subjects

Lung Cancer Treatments and Mutations CRISPR and Genetic Engineering Lung Cancer Research Studies

Publication details

Publication date: 12 January 2026