Figure S15 from EML4−ALK Variant-Specific Genetic Interactions Shape Lung Tumorigenesis

Supplementary Figure 15 shows additional data on the genomic landscape of human EML4-ALK-driven lung cancer, including breakpoints in EML4 and ALK for all samples in the EML4-ALK cohort, distribution of alteration counts for all genes queried in Foundation Medicine’s sequencing panel, genes with recurrent alterations that have not previously been shown to be altered in EML4-ALK-driven lung cancer, calculation of power to detect differences in mutation frequency between V1- and V3-driven tumors, and alteration counts for NOTCH genes and PTEN in samples with the indicated “long” and “short” EML4-ALK variants.