Figure S13 from EML4−ALK Variant-Specific Genetic Interactions Shape Lung Tumorigenesis

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Authors: Alberto Diaz-Jimenez, Emily G. Shuldiner, Kálmán Somogyi, Karen Y. Shih, Óscar González-Velasco, Mulham Najajreh, Stewart J. Kim, Filiz Akkas, Christopher W. Murray, Laura Andrejka, Min K. Tsai, Benedikt Brors
+8 more Ilse Hofmann, Smruthy Sivakumar, Saumya Dushyant Sisoudiya, Ethan S. Sokol, Hongchen Cai, Dmitri A. Petrov, Monte M. Winslow, Rocı́o Sotillo
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Abstract

Supplementary Figure 13 shows additional data on the differences in tumor suppressor effects across different oncogenic contexts including an example plot of correlation analysis with an explanation of comparisons, correlation in the rank order of tumor suppressive effects across different oncogenic contexts calculated across various values of Ni=basal,j=basal, and correlation in the rank order of tumor suppressive effects across different oncogenic contexts across various values of Ni=basal,j=basal with genes ranked by fold change in adaptively sampled 95th percentile tumor size.

Fields of Study & Subjects

Lung Cancer Treatments and Mutations Lung Cancer Research Studies Cancer Genomics and Diagnostics

Publication details

Publication date
12 January 2026