Supplementary Video 2 from Screening for Tumor Microtube–Targeting Drugs Identifies PKC Modulators as Multipotent Inhibitors of Glioblastoma Progression

2026 Open access

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Authors: Daniel Domínguez Azorín, Dirk C. Hoffmann, Nils R. Hebach, Erik Jung, David Hausmann, Miriam Ratliff, Ling Hai, Sandra Horschitz, Ammar Jabali, Matthias Osswald, Matthia A. Karreman, Tobias Kessler
+18 more Susann Wendler, Chanté D. Mayer, Cathrin Löb, Pascal Lehnert, Gina Cebulla, Denise Reibold, Rajiv K. Khajuria, Pino Bordignon, Andreas E. Moor, Tim Holland-Letz, Jill Reckless, Nigel G. Ramsden, David Grainger, Anna Kreshuk, Philipp Koch, Wolfgang Wick, Sophie Heuer, Frank Winkler
DOI: 10.1158/2159-8290.31276667
Cited by: 0

Abstract

Live cell confocal Ca2+ imaging of patient-derived GBSCs (S24) within a monolayer 2DTM in vitro assay. This assay fosters GBSC interconnection via TMs, resulting in a dense anatomical network with pronounced Ca2+ (co-)activity. Tumor cells are stained with the Rhod-2AM Ca2+ sensor

Fields of Study & Subjects

Glioma Diagnosis and Treatment Cancer Cells and Metastasis Mathematical Biology Tumor Growth

Publication details

Publication date
6 February 2026