Supplementary Video 1 from Screening for Tumor Microtube–Targeting Drugs Identifies PKC Modulators as Multipotent Inhibitors of Glioblastoma Progression

Daniel Domínguez Azorín; Dirk C. Hoffmann; Nils R. Hebach; Erik Jung; David Hausmann; Miriam Ratliff; Ling Hai; Sandra Horschitz; Ammar Jabali; Matthias Osswald; Matthia A. Karreman; Tobias Keßler; Susann Wendler; Chanté D. Mayer; Cathrin Löb; Pascal Lehnert; Gina Cebulla; Denise Reibold; Rajiv K. Khajuria; Pino Bordignon; Andreas E. Moor; Tim Holland-Letz; Jill Reckless; Nigel G. Ramsden; David Grainger; Anna Kreshuk; Philipp Koch; Wolfgang Wick; Sophie Heuer; Frank Winkler

doi:10.1158/2159-8290.31276670

Supplementary Video 1 from Screening for Tumor Microtube–Targeting Drugs Identifies PKC Modulators as Multipotent Inhibitors of Glioblastoma Progression

2026 Open access

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Authors: Daniel Domínguez Azorín, Dirk C. Hoffmann, Nils R. Hebach, Erik Jung, David Hausmann, Miriam Ratliff, Ling Hai, Sandra Horschitz, Ammar Jabali, Matthias Osswald, Matthia A. Karreman, Tobias Keßler

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Susann Wendler, Chanté D. Mayer, Cathrin Löb, Pascal Lehnert, Gina Cebulla, Denise Reibold, Rajiv K. Khajuria, Pino Bordignon, Andreas E. Moor, Tim Holland-Letz, Jill Reckless, Nigel G. Ramsden, David Grainger, Anna Kreshuk, Philipp Koch, Wolfgang Wick, Sophie Heuer, Frank Winkler

DOI: 10.1158/2159-8290.31276670

Cited by: 0

Abstract

Live cell confocal recording of patient-derived GBSCs (S24), in classical neurosphere conditions where TMs and Ca2+ activity are not observed. Rhodamine-2 AM (Rhod-2AM) was used to track Ca2+ activity

Fields of Study & Subjects

Glioma Diagnosis and Treatment Cancer Cells and Metastasis Protein Kinase Regulation and GTPase Signaling

Publication details

Publication date: 6 February 2026