Supplementary Video 5 from Screening for Tumor Microtube–Targeting Drugs Identifies PKC Modulators as Multipotent Inhibitors of Glioblastoma Progression

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Authors: Daniel Domínguez Azorín, Dirk C. Hoffmann, Nils R. Hebach, Erik Jung, David Hausmann, Miriam Ratliff, Ling Hai, Sandra Horschitz, Ammar Jabali, Matthias Osswald, Matthia A. Karreman, Tobias Kessler
+18 more Susann Wendler, Chanté D. Mayer, Cathrin Löb, Pascal Lehnert, Gina Cebulla, Denise Reibold, Rajiv K. Khajuria, Pino Bordignon, Andreas E. Moor, Tim Holland-Letz, Jill Reckless, Nigel G. Ramsden, David Grainger, Anna Kreshuk, Philipp Koch, Wolfgang Wick, Sophie Heuer, Frank Winkler
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Abstract

In vivo multiphoton 3D volume of a S24 tumor growing in a mouse brain under a chronic cranial window, analyzed with the newly developed 3D morphometry pipeline. S24 GBSCs are green (GFP) and the predicted TMs and cell bodies can be visualized in different colors. Orthogonal planes are used to visualize the overlaps between the algorithm predictions and the raw data

Fields of Study & Subjects

Glioma Diagnosis and Treatment Mathematical Biology Tumor Growth Cancer Cells and Metastasis

Publication details

Publication date
9 February 2026
Language
EN