Supplementary Video 4 from Screening for Tumor Microtube–Targeting Drugs Identifies PKC Modulators as Multipotent Inhibitors of Glioblastoma Progression

2026 Open access

Read full text
Authors: Daniel Domínguez Azorín, Dirk C. Hoffmann, Nils R. Hebach, Erik Jung, David Hausmann, Miriam Ratliff, Ling Hai, Sandra Horschitz, Ammar Jabali, Matthias Osswald, Matthia A. Karreman, Tobias Kessler
+18 more Susann Wendler, Chanté D. Mayer, Cathrin Löb, Pascal Lehnert, Gina Cebulla, Denise Reibold, Rajiv K. Khajuria, Pino Bordignon, Andreas E. Moor, Tim Holland-Letz, Jill Reckless, Nigel G. Ramsden, David Grainger, Anna Kreshuk, Philipp Koch, Wolfgang Wick, Sophie Heuer, Frank Winkler
DOI: 10.1158/2159-8290.31296587
Cited by: 0

Abstract

Ca2+ imaging was performed on the 2DTM assay with tumor cells stained with Rhod-2AM Ca2+ sensor and visualized using live-cell confocal microscopy. Treatment with the PKC activator (TPPB, 1 μM) resulted in a marked reduction of global Ca2+ activity across the tumor cell network compared to the DMSO control

Fields of Study & Subjects

Glioma Diagnosis and Treatment Protein Kinase Regulation and GTPase Signaling Cancer Cells and Metastasis

Publication details

Publication date
9 February 2026
Language
EN