Shaping the Tumor Microenvironment: Insights from Host–Microbiota Interactions

Cancer Discovery 2026

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Authors: Khiem C. Lam, Romina S. Goldszmid
DOI: 10.1158/2159-8290.cd-25-1350
Cited by: 2
References: 19

Abstract

Gut microbiota has emerged as a determinant of cancer therapy efficacy, shaping immune responses both systemically and locally within the tumor microenvironment. In this piece, we discuss current insights into the mechanistic basis of these interactions, with a focus on type I interferon as a central mediator of microbiota-driven immune modulation.

Fields of Study & Subjects

Gut microbiota and health Cancer Immunotherapy and Biomarkers Immune cells in cancer

Publication details

Journal / source
Cancer Discovery
Publisher
American Association for Cancer Research (AACR)
Volume
16
Issue
2
Pages
213–217
Publication date
6 February 2026
Language
EN