Holding the Line: Negative Selection Maintains the Karyotype in Metastatic Colorectal Cancer

Cancer Discovery 2026

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Authors: Hajime Okada, Rachel Slutsky, Uri Ben‐David
DOI: 10.1158/2159-8290.cd-25-1430
Cited by: 0
References: 11

Abstract

Aneuploidy is prevalent across human cancers, yet its specific contributions to tumor evolution remain poorly understood. In this issue, Cross, Nowinski, Cresswell, Mossner, and colleagues present a longitudinal analysis of 755 samples from 167 patients with colorectal cancer, uncovering the temporal dynamics of karyotype evolution in this tumor type. See related article by Cross et al., p. 218.

Fields of Study & Subjects

Cancer Genomics and Diagnostics Genetic factors in colorectal cancer Colorectal Cancer Treatments and Studies

Publication details

Journal / source
Cancer Discovery
Volume
16
Issue
2
Pages
192–194
Publication date
6 February 2026
Language
EN