Plasticity as Resistance: KRAS Inhibition Reveals WNT Adaptation in Metastatic Colorectal Cancer
Abstract
Centonze and colleagues demonstrate that KRASG12D inhibition in metastatic colorectal cancer triggers rapid transcriptional reprogramming from a metastasis-associated EMP1+ state to a WNT-driven LGR5+ stem cell-like state, a plastic adaptation captured through real-time live cell imaging, revealing cell state conversion as a mechanism of therapeutic resistance that can be exploited through combinatorial targeting. See related article by Centonze et al., p. 320.
Fields of Study & Subjects
Wnt/β-catenin signaling in development and cancer
Cancer Cells and Metastasis
Cellular Mechanics and Interactions
Publication details
- Journal / source
- Cancer Discovery
- Publisher
- American Association for Cancer Research (AACR)
- Volume
- 16
- Issue
- 2
- Pages
- 201–203
- Publication date
- 6 February 2026
- Language
- EN