Inflammation-Driven Field Cancerization in End-Stage Kidney Disease
Abstract
In this issue, Takahashi, Tanaka, and colleagues provide a comprehensive genomic, transcriptomic, and spatial analysis of renal cell carcinomas (RCC) associated with end-stage renal disease. They demonstrate that the clonal expansion of a subset of proximal tubule cells, supported by an inflammatory microenvironment, gives rise to the cysts of acquired cystic kidney disease as well as to acquired cystic disease-associated RCC. See related article by Takahashi et al., p. 478.
Fields of Study & Subjects
Renal cell carcinoma treatment
Bladder and Urothelial Cancer Treatments
Infectious Disease Case Reports and Treatments
Publication details
- Journal / source
- Cancer Discovery
- Publisher
- American Association for Cancer Research (AACR)
- Volume
- 16
- Issue
- 3
- Pages
- 426–427
- Publication date
- 2 March 2026
- Language
- EN