Neoantigen Vaccine Spurs Broad Immune Responses
Abstract
A neoantigen vaccine against 209 frameshift peptides elicited strong, broad, and long-lasting immunity in people with Lynch syndrome in a phase Ib/II study, offering a novel approach for preventing the range of cancers these individuals are at an elevated risk of developing.
Fields of Study & Subjects
Immunotherapy and Immune Responses
Cancer Immunotherapy and Biomarkers
vaccines and immunoinformatics approaches
Publication details
- Journal / source
- Cancer Discovery
- Volume
- 16
- Issue
- 4
- Pages
- OF1–OF1
- Publication date
- 11 February 2026
- Language
- EN