Supplementary Figure S6 from T-cell Subset Features and Distributions Evolve across the Colorectal Precancer–Cancer Spectrum

Supplementary Figure S6. Intraepithelial and lamina propria/stromal CD3+CD4+ and CD3+CD8+ T-cell density (/mm2) stratified by tissue dysplasia grade [low-grade dysplasia (LGD) and high-grade dysplasia (HGD)] and tissue categories, which include colorectal normal mucosa, non-serrated lesions with LGD or HGD, and colorectal carcinoma. (A-F) Intraepithelial CD3+CD4+ and CD3+CD8+ T-cell densities were classified by T-cell differentiation status [CD45RA+CD45RO- (naive) and CD45RA-CD45RO+ (memory)] and functional status [FOXP3+ (regulatory)]. (G-L) Lamina propria/stromal CD3+CD4+ and CD3+CD8+ T-cell densities were classified by T-cell differentiation status (naive and memory) and functional status (regulatory). P values were calculated with the Mann-Whitney U test (Wilcoxon rank-sum test) as compared to colorectal normal mucosa near precursor lesions. ***: P