Supplementary Figure S5 from T-cell Subset Features and Distributions Evolve across the Colorectal Precancer–Cancer Spectrum

Supplementary Figure S5. Intraepithelial and lamina propria/stromal CD3+CD4+ and CD3+CD8+ T-cell densities were stratified by specimen types, which include colorectal normal mucosa, non-serrated adenomas, serrated lesions, invasive carcinoma, and normal mucosa near invasive carcinoma. CD3+CD4+ T-cell and CD3+CD8+ T-cell densities were stratified by T-cell differentiation status [CD45RA+CD45RO- (naive) and CD45RA-CD45RO+ (memory)], and functional status [FOXP3+ (regulatory), consisting of FOXP3+Low and FOXP3+High] in the intraepithelial (A-J) and lamina propria/stromal (K-T) tissue regions. P values were calculated with the Mann-Whitney U test (Wilcoxon rank-sum test) as compared to normal mucosa near precursor lesions (normal) and carcinoma. ***: P