Figure S8 from RAS(ON) Multiselective Inhibition Drives Antitumor Immunity in Preclinical Models of NRAS-Mutant Melanoma

Supplemental Figure 8: The RMC-7977 + anti-PD1 combination reprograms the tumor microenvironment to a more pro-inflammatory state. (A) Dot plot showing the expression of canonical marker genes across different myeloid cell clusters identified in single-cell RNA sequencing. (B) Dot plot showing the expression of top marker genes across different cell clusters identified in single-cell RNA sequencing. Each column corresponds to a distinct cell type identity, and each row represents a gene of interest. The size of each dot indicates the proportion of cells within the corresponding identity group that express the gene (percent expressing), as shown by the dot size legend on the bottom right. The color of the dots represents the average gene expression level (scaled), according to the color scale on the right (from blue for high expression to yellow to low expression).