Figure S7 from RAS(ON) Multiselective Inhibition Drives Antitumor Immunity in Preclinical Models of NRAS-Mutant Melanoma

Supplemental Figure 7: The RMC-7977 + anti-PD1 combination reprograms the tumor microenvironment to a more pro-inflammatory state. (A) UMAP plot showing the distribution of myeloid cells. (B) Cluster frequency distribution of myeloid cells in the control (vehicle + IgG), Anti-PD1, RMC-7977 and RMC-7977 + Anti-PD1 groups. (C) UMAP plot showing the distribution of myeloid cells subtypes. (D) Cluster frequency distribution of myeloid cell subtypes in the control (vehicle + IgG), Anti-PD1, RMC-7977 and RMC-7977 + Anti-PD1 groups. R1, R2 and R3: replicates.