Supplemental Table 1 from WTX-124, a Conditionally Activated Wild-Type IL2, Maximizes the Therapeutic Index of IL2, Unlike “Non-Alpha” Muteins

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Authors: Christopher J. Nirschl, Kulandayan K. Subramanian, Heather R. Brodkin, Celesztina Domonkos, Connor J. Dwyer, Daniel J. Hicklin, RANDI E. ISAACS, Nesreen S. Ismail, Julie LePrevost, Yuka Lewis, Kristin R. Morris, Cynthia Seidel‐Dugan
+5 more Zoe Steuert, Jenna M. Sullivan, Sameer S. Chopra, Andrés Salmerón, William M. Winston
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Abstract

Tumors were implanted and INDUKINE treatment was performed as described in Figure 2. RNA from each tumor was isolated on day 5 and subjected to immune profiling with the NanoString nCounter PanCancer Mouse Immune Profiling panel. Table includes the Z scores of transcripts with statistically significant differences (p < 0.05) in expression between the vehicle group and either treatment group. Each column represents the gene expression profile of the tumor from an individual animal.

Fields of Study & Subjects

Cancer Immunotherapy and Biomarkers Immunotherapy and Immune Responses T-cell and B-cell Immunology

Publication details

Publication date
4 March 2026
Language
EN